T cell apoptosis by tryptophan catabolism
نویسندگان
چکیده
منابع مشابه
Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
We have recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO) during murine pregnancy is required to prevent rejection of the allogeneic fetus by maternal T cells. In addition to their role in pregnancy, IDO-expressing cells are widely distributed in primary and secondary lymphoid organs. Here we show that monocytes that have differentiated under the influence of macro...
متن کاملPrognostic significance of tryptophan catabolism in adult T-cell leukemia/lymphoma Short title: Tryptophan catabolism in ATL Authors:
Institutions: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Laboratory of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences,Department of Tumor Immunology, Aichi Medical University School of ...
متن کاملSuppression of memory CD8 T cell generation and function by tryptophan catabolism.
Dendritic cell-derived indoleamine 2,3-dioxygenase (IDO) suppresses naive T cell proliferation and induces their apoptosis by catalyzing tryptophan, and hence is essential for the maintenance of peripheral tolerance. However, it is not known whether memory T cells are subject to the regulation by IDO-mediated tryptophan catabolism, as memory T cells respond more rapidly and vigorously than thei...
متن کاملMonocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation.
T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative responses to polyclonal stimulation of post-HSCT peripheral blood mononuclear cells (PB-MCs) were markedly (4-fold) improved by T-cell enrichment. Conversely, addback of post-HSCT monocytes to these enriche...
متن کاملBiology of Human Tumors Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma
Purpose: Indoleamine 2,3-dioxygenase 1 (IDO1: IDO), an enzyme catabolizing tryptophan (Trp) into the kynurenine (Kyn) pathway, is increasingly being recognized as an important microenvironmental factor suppressing antitumor immune responses. The purpose of the present study was to determine the prognostic significance of Trp catabolism in adult T-cell leukemia/lymphoma (ATL). Experimental Desig...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2002
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4401073